In the obstetrical population, infection continues to be  the most frequent complication of a cesarean delivery. Antibiotic prophylaxis for all cesarean sections is recommended by the Centers of Disease Control and Prevention (CDC) as a strategy to reduce surgical site infections. The American College of Obstetricians and Gynecologists (ACOG) recommends the use of prophylactic antibiotics for the cesarean section patient identified as High Risk: a laboring patient with or without rupture of membranes. Literature indicates that antibiotic prophylaxis is utilized inconsistently in clinical practice. Inconsistencies include the rate of utilization, choice of antimicrobial agent, and timing of  antimicrobial delivery.  Similar inconsistencies in antibiotic delivery were identified in the cesarean section population at  a tertiary obstetrical unit. A collaborative effort among health care providers was initiated to standardize antibiotic delivery to those cesarean section patients identified as High Risk. Since the development of the MD order set, the team recommended subsequent practice changes based on continued literature review on best practice in reducing the inciident of SSI. Since then two additional practice changes, timing of prophylactic antibiotic and surgical prep, have been incrementatlly insitituted  to further reduce the incidence of SSI that would decrease the number of hospital days, decrease hospital readmission for antibiotic therapy, decrease overall health care cost, and prevent disruption of the maternal - newborn bonding process. The  presentation will include strategies instituted to reduce the incidence of SSI  in the OB population with correlating data  demonstrating  the effectiveness of each practice change.